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KMID : 0811720020060000169
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Korean Journal of Physiology & Pharmacology
2002 Volume.6 No. 0 p.169 ~ p.0
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Decrease in Spinal μ-opioid Receptor is Related to Neuropathic Pain in a Rat Model
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Back Seung-Keun
Hong Seung-Kil
Na Heung-Sik
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Abstract
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Peripheral nerve injury often leads to chronic neuropathic pain, and results in the reduction of spinal μ-opioid receptors. However, the relationship between neuropathic pain and the decrease in spinal μ- opioid receptor is not yet clear.
We examined whether the extent of decrease in spinal μ-opioid receptors following peripheral nerve injury was related to the generation of neuropathic pain. To this aim, we compared the degree of reduction of spinal μ-opioid receptor in the two groups of rats, both of which were subjected to unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves; one group exhibited well-developed mechanical allodynia after the nerve injury, whereas the other group showed poorly developed signs despite the same nerve injury. The significant reduction of μ-opioid receptor-immunoreactivity (ir) in the injured side was seen in both groups. However, the decrease in μ-opioid receptor-ir was more pronounced in the well-developed group than in the poorly developed group. These results suggest that the extent of reduction of μ-opioid receptor in the spinal cord following peripheral nerve injury is proportionally related to the severity of neuropathic pain.
Source: Korean Journal of Physiology & Pharmacology.2002 Oct;6(Suppl II):S114-S114
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KEYWORD
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spinal opioid receptor, neuropathic pain, mechanical allodynia
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